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News for Healthier Living

Pain and Antidepressant Drug Combo Linked to Increased Seizure Risk in Older Adults

When older adults living in nursing homes are prescribed the pain medicine tramadol alongside certain antidepressants, their risk of seizures may go up, according to a study published October 8, 2025, in Neurology(r), the medical journal of the American Academy of Neurology. While this study found a link between using the medications together and an increased risk of seizures, it does not prove one causes the other.

October 8, 2025


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