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News for Healthier Living

Unlocking the Role of Lcn2 in COVID-19 Lung Damage

A new study reveals that the protein Lcn2, secreted by lung macrophages, plays a central role in exacerbating severe pneumonia caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Researchers developed a lethal pneumonia mouse model using an adapted viral strain and found that elevated levels of Lcn2 directly correlate with disease severity. Lcn2 not only enhanced inflammatory signaling and neutrophil adhesion but also disrupted endothelial barriers, leading to heightened lung damage. This research sheds light on a critical pathway--NLRP3-mediated Lcn2 secretion--that drives the escalation of inflammation in the lungs. The findings suggest Lcn2 as a potential diagnostic marker and therapeutic target for severe respiratory infections such as COVID-19.

June 30, 2025


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